1. “Proliferative disorders”

2. “Proliferative disorders”
Proliferation of a clone of cells
Lymphoid
Myeloid

3. lymphoproliferative disorders
A clone of malignant lymphocytes fills the bone marrow
The lymphoid leukaemias are discussed in other presentations

4. lymphoproliferative disorders
The lymphomas
Hodgkins’s Lymphoma
Non - Hodgkins’ Lymphoma
The rare ones: Burkitt’s Lymphoma
Mycosis Fungoides
Sezary’s Symdrome
Conditions can be staged
Range of severity of disease

5. lymphoproliferative disorders
Myeloma / Waldenstrom’s Macroglobulinaemia
Proliferation of plasma cells
All producing one antibody

6. myeloproliferative disorders
A clone of malignant myeloid cells fills the bone marrow
The myeloid leukaemias are discussed in other presentations

7. myeloproliferative disorders
Polycythaemia Rubra Vera
As opposed to secondary polycythaemias
Proliferation of red cell production
Often other cell lines proliferate too

8. myeloproliferative disorders
Essential thrombocythaemia
Grossly excessive platelet production - >400 x109cells/l

9. myeloproliferative disorders
Myelofibrosis
Bone marrow fills with fibrous tissue

10. myeloproliferative disorders
Raised cell counts cause problems:
Red cells - circulatory overload
Platelets - thrombotic risk

11. myeloproliferative disorders
MPDs are all “preleukemic” and are predisposed to clonal evolution and disease transformation to AML.
The propensity to transform into AML differs among the subgroups, being highest for CML (>90%) and least for ET (<5%).
Patients with PV have a 10 and 25% chance of transforming into a myelofibrotic stage at 10 and 25 years of follow-up, respectively.