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“Sweet Talk”: Closing in on C Type Lectin Signaling

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1 “Sweet Talk”: Closing in on C Type Lectin Signaling
Friederike Meyer-Wentrup, Alessandra Cambi, Gosse J. Adema, Carl G. Figdor  Immunity  Volume 22, Issue 4, Pages (April 2005) DOI: /j.immuni Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 The Yeast Cell Wall (Zymosan) Can Interact with the PRRs Dectin-1 and TLR2 Receptor triggering has diverse effects, ranging from IL-2 and IL-10 production in the case of Dectin-1 triggering alone to IL-12 and TNF-α production in the case of TLR2 activation. The latter is augmented by cooperative signaling of Dectin-1 with TLR2. One of the future challenges is to determine the mechanisms regulating the interplay between different receptors after pathogen binding. Immunity  , DOI: ( /j.immuni ) Copyright © 2005 Elsevier Inc. Terms and Conditions


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