1. New Antiepileptic Drugs

2. Program Goals

3. Epilepsy Prevalence in the United States

4. Age and Prevalence of Epilepsy

5. Success in AED Regimens (%)

6. What Is Rational Polytherapy?

7. Proposed MOA of AEDs Enhance GABAergic Neuromodulation

8. Proposed MOA of AEDs Reduce Glutamate-Mediated Excitatory Modulation

9. Synergistic Drug Combinations

11. Lacosamide PK Profile

12. Lacosamide as Adjunctive Therapy Most Common TEAEs

13. Lacosamide Monotherapy Conversion Trial KM-Estimated 112-Day Exit Rate

14. Eslicarbazepine Acetate Approved as Monotherapy or Adjunctive Therapy for Patients With POS

16. Eslicarbazepine Pharmacokinetics

17. Eslicarbazepine as Adjunctive Therapy 50% or Greater Reduction in Seizure Frequency

18. Eslicarbazepine as Adjunctive Therapy Most Common TEAEs

22. Proposed MOA of AEDs

23. Perampanel

26. Perampanel for Refractory PGTC Seizures

28. New SV2A Modulators

29. Molecular Targets of AEDs Where Does This Leave Us?

30. Abbreviations

31. Abbreviations (cont)