1. CMV: when bad viruses turn good
by A. John Barrett
Blood
Volume 118(5):
August 4, 2011
©2011 by American Society of Hematology

2. Hypothetical mechanisms of a virus-versus-leukemia effect.
Hypothetical mechanisms of a virus-versus-leukemia effect. The myeloid reservoir of latent CMV virus includes AML blasts that reactivate after SCT. (1) CMV-specific CTLs kill CMV antigen presented by leukemia; (2) CMV up-regulates LFA-1 in leukemia, increasing susceptibility to NK killing; (3) direct cytotoxic effect of CMV on AML cells.
A. John Barrett Blood 2011;118:
©2011 by American Society of Hematology