1. Taylor Brewer, Darian Buck, Izabella Castillo, and Justin Hadad
Sex and Gender Show
YOUR HOSTS
Taylor Brewer, Darian Buck, Izabella Castillo, and Justin Hadad

2. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

3. Hormonal
Influencers
100
A deficiency in androgen will primarily affect:
A mother’s ability to nurse.
A male’s testosterone levels.
A female’s fertility.
B. A male's testosterone levels

4. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

5. Hormonal
Influencers
200
A frameshift mutation in the HSD3B2 gene will most likely result in which of the following:
Increased enzymatic activity
Complete virilization of males at birth
Virilization in females at birth
C. Virilization in females at birth

6. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

7. Hormonal
Influencers
300
What might one expect to be shared between a girl with ambiguous genitalia and a boy with an enlarged penis?
Low cortisol levels
High stress levels
(45, X0) karyotype
Hypopituitarism
B. High stress levels

8. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

9. Genetic
Studies
100
Initial gene responsible for male sex determination:
FOXL2
b) SRY
c) SOX9
ANSWER: B- SRY

10. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

11. Genetic
Studies
200
The XIST gene silences the expression of other genes on regions of the X chromosome. What basic biological phenomenon is at work here?
Answer: EPISTASIS

12. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

13. Genetic
Studies
300
Scientists studied DBX, UTX, and other genes expressed on both the X and Y chromosomes to analyze differential gene expression. Scientists discover that each gene is independently expressed the same amount on each chromosome. What does this mean?
The human benefited from equal, normal expression; leading to a mutation that equalized expression on each chromosome
The genes on the X chromosome escaped X chromosome inactivation
The only way this is possible is through PCR
In situ hybridization occurred B

14. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

15. potpourri
100
According to Dr. Patrick Harrison, what is the origin of binary gender and sex?
ANSWER: in group/ out group

16. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

17. potpourri
200
What do we define as “the ability of individual genotypes to produce different phenotypes when exposed to different environmental conditions?”
Plasticity

18. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

19. potpourri
300
Name four of the seven genes that we discussed that alter one’s identification of gender.
ANSWER: RPS4, UT, SMC, XIST, DB, USP9, VC

20. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

21. Mutations and Atypicalities 100
The common genetic atypicality (45, X0) in a phenotypic female is

22. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

23. Mutations and Atypicalities
200
An autosomal dominant mutation in the SOX9 gene results in:
Testicular DSD with male phenotype
Atypicality in genitalia ranging from ambiguity to female phenotypes
Klinefelter's Syndrome

24. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

25. Mutations and Atypicalities
300
For 100 points each, name three traits of a female with (46, XX) testicular DSD sex atypicality. XX
Small testes
Male external genitals
Presence of SRY

26. Mutations and Atypicalities
~ c o m e o n d o w n ~
TOPICS
Hormonal Influencers
Genetic Studies
Potpourri
Mutations and Atypicalities
100
200
300

27. WINNER