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Where does a Staphylococcus aureus vaccine stand?

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Presentation on theme: "Where does a Staphylococcus aureus vaccine stand?"— Presentation transcript:

1 Where does a Staphylococcus aureus vaccine stand?
V.G. Fowler, R.A. Proctor  Clinical Microbiology and Infection  Volume 20, Pages (May 2014) DOI: / Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1. Abbreviations MΦ, macrophage; PSM, phenol-soluble modulins; IL, interleukin; TGF-β, transforming growth factor-β; Th17, T helper type 17 cells; mAb, monoclonal antibody; V710, IsdB antigen used in Merck Vaccine trial; C', complement; SAE, Staphylococcus aureus enterotoxin E; RORγ(, retinoid-related orphan receptor γ; STAT3, signal transducer and activator of transcription 3; Hla, α-toxin; TSST-1, toxic shock syndrome toxin -1; Luk, leucocidin; PVL, Panton-Valentine leucocidin (two component toxin made up of LukS-PV and LukF-PV); IFN-γ, interferon-γ. Clinical Microbiology and Infection  , 66-75DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions


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