1. Depth of Conservation (May/20/2010)
Giltae Song, Bob Harris
Penn State
Center for Comparative Genomics and Bioinformatics

2. Our Question: Do different elements exhibit
different conservation profiles?

3. Alignable Proportion Alignable Proportion = fraction of
intervals that are at least half aligned

4. Alignable Proportion Measured for each human-vs-other alignment,
Plotted at human-to-other distance

5. Alignable Proportion Unnormalized

6. Alignable Proportion Unnormalized
Low Coverage Genomes

7. Alignable Proportion—Normalized
Normalize by dividing by alignable
proportion of coding exons

8. Alignable Proportion—Normalized
Curve fit through “distant” high coverage
assemblies (species names in black)

9. Alignable Proportion Envelopes

10. Alignable Proportion—Class 22

11. Alignable Proportion—Class 3

12. Alignable Proportion—Class 8

13. Alignable Proportion—Class 6

14. Similar measure for species/depth conservation of TFBS motifs
Ongoing
Similar measure for species/depth conservation of TFBS motifs
More plots via