1. Tailoring Hemophilia Prophylaxis Therapy

3. Program Goal

4. Overview

5. Case 1: A Newly Diagnosed Patient With Severe Hemophilia A

6. Case 1 Presentation (cont)

7. Would You Consider Prophylaxis With Prolonged Half-life FVIII in This Patient?

8. Examples of Prolonged Half-life Factor Products

9. Entering Infants Into Clinical Trials

10. Potential Benefits of Prolonged Half-life Factor Productsa-c

11. Case 2: An Older Man With Severe Hemophilia B

12. Case 2 Presentation (cont)

13. Case 2 Presentation (cont)

14. Considerations Regarding Use of Prolonged Half-life Factor Products in Older Patients

15. Considerations Regarding Use of Prolonged Half-life Factor Products in Older Patients (cont)

16. Additional Considerations Regarding Use of Prolonged Half-life Products

17. Additional Considerations Regarding Use of Prolonged Half-life Products (cont)

18. Case 3: Inhibitor Development in a Patient With Severe Hemophilia

19. Options for Inhibitor Development in a Patient With Hemophilia B

20. Concluding Comments

21. Abbreviations

22. References

23. References (cont)

24. References (cont)

25. References (cont)

26. References (cont)