1. Breast Tumor Heterogeneity: Source of Fitness, Hurdle for Therapy
Shany Koren, Mohamed Bentires-Alj 
Molecular Cell 
Volume 60, Issue 4, Pages (November 2015)
DOI: /j.molcel
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Model of Mammary Cell Hierarchy
During embryonic development, MaSCs contribute to the luminal and basal lineages. Currently, the existence of adult multipotent MaSCs is under debate. Self-sustained unipotent luminal and basal stem cells as well as multipotent stem cells may maintain the homeostasis of the adult virgin mammary gland. The organization of their hierarchy is unknown.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2015 Elsevier Inc. Terms and Conditions

3. Figure 2 Sources of Breast Cancer Heterogeneity
Schematic illustration of possible sources of heterogeneity.
(A) Combination of the differentiation state of the cell-of-origin and the tumor-initiating genomic alteration ([A] or [B]) is a determinant of the tumor phenotype.
(B) Cell plasticity contributes to the phenotypic diversity of breast cancer. Dynamic bidirectional cell conversions occur between CSCs and non-cancer stem cells within a tumor.
(C) Tumorigenesis is a multi-step branched evolutionary process. Phylogenetic lineages of clones form by genomic alteration and Darwinian selection. This genomic heterogeneity translates into phenotypic tumor heterogeneity.
(D) Interaction and cross-talk between tumor cells and their microenvironment impact tumor diversity.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2015 Elsevier Inc. Terms and Conditions