1. The Actions of the Three Proton Pumps and ATP Synthase
Process Diagrams Step-by-Step
Copyright © 2007 by John Wiley & Sons, Inc.

2. + + + + + + + – – – – – – – 1 Space between outer
and inner mitochondrial
membranes
H+ channel + H+ + + + + + +
Inner
mito-
chondrial
membrane Q e– – – – – – – –
Mitochondrial
matrix
NADH
+ H+
NAD 1
NADH dehydrogenase
complex: FMN and
five Fe-S centers

3. + + + + + + + – – – – – – – 1 2 Space between outer
and inner mitochondrial
membranes
H+ channel + H+ + + + + + +
Cyt c
Inner
mito-
chondrial
membrane e– Q e– e– – – – – – – –
Mitochondrial
matrix
NADH
+ H+
NAD H+ 1 2
NADH dehydrogenase
complex: FMN and
five Fe-S centers
Cytochrome b-c1
complex: cyt b, cyt c1,
and an Fe-S center

4. + + + + + + + – – – – – – – 3 1 2 3 Space between outer
and inner mitochondrial
membranes
H+ channel H+ + H+ + + + + + H+ +
Cyt c
Inner
mito-
chondrial
membrane e– e– Q e– e– e– – – – – – – –
Mitochondrial
matrix 3
1 1/2 O2
NADH
+ H+
NAD H+
ADP + P 3
H2O
ATP
ATP synthase 1 2 3
NADH dehydrogenase
complex: FMN and
five Fe-S centers
Cytochrome b-c1
complex: cyt b, cyt c1,
and an Fe-S center
Cytochrome oxidase
complex: cyt a,
cyt a3,and two Cu