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Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’ acute kidney injury?: con  Dileep N. Lobo, Sherif.

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Presentation on theme: "Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’ acute kidney injury?: con  Dileep N. Lobo, Sherif."— Presentation transcript:

1 Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’ acute kidney injury?: con  Dileep N. Lobo, Sherif Awad  Kidney International  Volume 86, Issue 6, Pages (December 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions

2 Figure 1 Rationale for fluid resuscitation to prevent acute kidney injury. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

3 Figure 2 Schematic diagram of the sequential effects of hyperchloremia on the kidney. Numbers indicate the sequence of events. A1-receptor, adenosine1-receptor. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

4 Figure 3 Adverse events related to intravenous therapy with 0.9% saline when compared with balanced crystalloids. The evidence has been collected from animal studies, healthy volunteer studies, small randomized clinical trials, and large patient cohort studies, and cannot be presently regarded as Grade A. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions


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