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Survival outcomes and interval between lymphoscintigraphy and SLNB in cutaneous melanoma- findings of a large prospective cohort study  Fionnuala M. O'Leary,

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Presentation on theme: "Survival outcomes and interval between lymphoscintigraphy and SLNB in cutaneous melanoma- findings of a large prospective cohort study  Fionnuala M. O'Leary,"— Presentation transcript:

1 Survival outcomes and interval between lymphoscintigraphy and SLNB in cutaneous melanoma- findings of a large prospective cohort study  Fionnuala M. O'Leary, Clare J. Beadsmoore, Davina Pawaroo, John Skrypniuk, Martin J. Heaton, Marc D. Moncrieff  European Journal of Surgical Oncology  Volume 44, Issue 11, Pages (November 2018) DOI: /j.ejso Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Terms and Conditions

2 Fig. 1 Comparison of distribution of timing of lymphoscintigraphy by year. Patients were divided into two cohorts (2008–2011 and 2012–2015) and the proportion of patients undergoing lymphoscintigraphy early (<12 h) was compared with late (>12 h). The results show showed a decrease in early lymphoscintigraphy rate from 40.8% to 31.6% in the second cohort (Chi squared test p = 0.002). European Journal of Surgical Oncology  , DOI: ( /j.ejso ) Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Terms and Conditions

3 Fig. 2 Comparison of OS, DSS and nodal relapse rates in early versus late treatment groups. 2A Kaplan Meier survival curve, which shows that there is a reduction in OS of 10.6% (p = 0.01, HR 1.64 [1.13–2.38]) in patients undergoing SLNB > 12 h post Tc-99 m nanocolloid injections. 2B Kaplan Meier survival curve, which shows a significant reduction (p = 0.04) in DSS in patients undergoing SLNB > 12 h post Tc-99 m nanocolloid injections. 2C Kaplan Meier survival curve which does not show any significant difference (p = 0.67) in nodal relapse rates between early versus late treatment groups. European Journal of Surgical Oncology  , DOI: ( /j.ejso ) Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Terms and Conditions

4 Fig. 3 Comparison of OS in treatment groups according to time course. OS is compared between groups patients undergoing Tc99m-nanocolloid injections 6, 9, 12 and 18 h prior to sentinel lymph node biopsy using Kaplan Meier curves. The results show a significant difference (p < 0.003) between patients undergoing early versus late lymphoscintigraphy, with the greatest difference observed at 12 h. European Journal of Surgical Oncology  , DOI: ( /j.ejso ) Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Terms and Conditions


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