1. (Treatment Failure Trial)
RESPOND-2 Study Design
(Treatment Failure Trial)
Weeks 24 48 72
Arm 1 : SOC Comparator
CONTROL
PEG + RBV 4 wk
Placebo + PEG + RBV
44 wk
Follow-up 24 wk
TW 8 HCV-RNA Undetectable
SCREENING
Arm 2 : Response Guided Therapy
Follow-up 36 wk
PEG + RBV 4 wk
BOC + PEG + RBV 32 wk
TW 8 HCV-RNA Detectable/TW 12 Undetectable
Placebo + PEG + RBV 12 wk
Follow-up 24 wk
EXPERIMENTAL ARMS
Arm 3: SOC + Boceprevir
PEG + RBV 4 wk
BOC+ PEG + RBV 44 wk
Follow-up 24 wk