1. Osteoarthritis and Cartilage
Biocompatibility and degradation OF celecoxib loaded polyesteramide-microspheres after intra-Articular injection in a post-traumatic rat osteoarthritis model 
U. Timur, M. Janssen, J. Berard, T. Welting, L. van Rhijn, M. Gijbels, G. Mihov, J. Thies, P. Emans 
Osteoarthritis and Cartilage 
Volume 24, (April 2016)
DOI: /j.joca
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2. Figure 1. Entrapment of microspheres in the synovium
Figure 1. Entrapment of microspheres in the synovium. Haematoxylin & Eosin stained section of an OA knee 3 weeks after injection with celecoxib loaded microspheres (A) Thionin stained sections of OA-induced knees 3 weeks after injections with non-loaded microspheres(B) or celecoxib loaded microspheres (C). Red asterisks in (B) and (C) depict a giant cell.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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3. Figure 2. In vivo degradation of PEA-based microspheres
Figure 2. In vivo degradation of PEA-based microspheres. PEA levels in rat knees measured directly after injection. 3 weeks and 12 weeks after intra-articular injections with non-loaded or celecoxib loaded PEA microspheres Data are mean ± SEM. N = 6 *P < 0.05. ** P <  Because no degradation is to be expected directly post injection, we injected celecoxib loaded microspheres as controls at this time point.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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