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Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

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Presentation on theme: "Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation"— Presentation transcript:

1 Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation
Sandra Maday, Alison E. Twelvetrees, Armen J. Moughamian, Erika L.F. Holzbaur  Neuron  Volume 84, Issue 2, Pages (October 2014) DOI: /j.neuron Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Molecular Mechanisms of Axonal Transport
Microtubule motor proteins kinesin and dynein drive the movement of organelles, vesicles, RNA granules, and proteins along the axon. Kinesins drive anterograde transport outward from the soma, and dynein drives retrograde transport back from distal axon. However, most cargos have both motor types bound simultaneously. Cargo-bound motors are regulated by organelle-specific complements of scaffolding and adaptor proteins. To avoid either distal accumulation or distal depletion of cellular components, anterograde and retrograde axonal transport must be in balance. Neuron  , DOI: ( /j.neuron ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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