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Volume 136, Issue 4, Pages (April 2009)

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Presentation on theme: "Volume 136, Issue 4, Pages (April 2009)"— Presentation transcript:

1 Volume 136, Issue 4, Pages 1234-1241 (April 2009)
Hyperglycemia Increases Risk of Gastric Cancer Posed by Helicobacter pylori Infection: A Population-Based Cohort Study  Fumie Ikeda, Yasufumi Doi, Koji Yonemoto, Toshiharu Ninomiya, Michiaki Kubo, Kentaro Shikata, Jun Hata, Yumihiro Tanizaki, Takayuki Matsumoto, Mitsuo Iida, Yutaka Kiyohara  Gastroenterology  Volume 136, Issue 4, Pages (April 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Age- and sex-adjusted incidence rate of gastric cancer according to hemoglobin A1c levels. *P < .05 vs hemoglobin A1c 5.0%–5.9%. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Multivariate adjusted splines for hemoglobin A1c (%) and gastric cancer risk, relative to hemoglobin A1c = 5.5%. The double-dashed lines are the 95% confidence intervals for the splines. The risk-changing points (shown by knots) are the hemoglobin A1c values of 5.3%, 5.5%, and 6.5%. The risks are adjusted for age, sex, history of peptic ulcer disease, body mass index, serum total cholesterol, alcohol intake, smoking habits, and total dietary factors (intake of total energy, total fat, salt, vitamin A, vitamin B-1, vitamin B-2, vitamin C, and dietary fibers). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Age- and sex-adjusted and multivariate-adjusted hazard ratios and 95% confidence intervals of gastric cancer according to hemoglobin A1c level and Helicobacter pylori status. †Adjusted for age, sex, history of peptic ulcer disease, body mass index, serum total cholesterol, alcohol intake, smoking habits and total dietary factors (intake of total energy, total fat, salt, vitamin A, vitamin B-1, vitamin B-2, vitamin C, and dietary fibers). *P < .001 vs hemoglobin A1c ≤5.9% and Helicobacter pylori negative. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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