1. The Allele Frequency Spectrum in Genome-Wide Human Variation Data Reveals Signals of Differential Demographic History in Three World Populations
Gabor T. Marth, Eva Czabarka, Janos Murvai and Stephen T. Sherry. Genetics (2004)

2. Allele Frequency
Creation of a simple, closed mathematical formulation for the spectrum of expected allele frequencies in 3 nonstationary populations
A profile of demographic history using multi-epoch approach with piecewise constnat effective pop. Size
Advantage- very rapid generation of AFS under a large number of competing histories
Circumvention

3. Model fitting to observed allele frequency spectra
Producing an equivalent distribution of allele frequencies at a lower sample size

4. European spectra As generations mutations Bottleneck-shaped history
Distribution of mutation times (1000x)
As generations mutations
Bottleneck-shaped history
Observed allelil frequency

5. Conclusion
This allele frequency spectrum is an excellent source for modeling demographic history
Independent of recombination and local variation in SNP rates
Requires measurements at allelic states only
Circumvent traditional problems