1. Fungi
“a group of diverse and widespread unicellular and multicellular organisms, lacking chlorophyll, usually bearing spores and often filamentous”

2. Fungal Infections 10 years nosocomial
organic compounds and carbon: energy
aerobic or facultatively anaerobic

3. Categories of Fungi
1) yeasts
2) molds
3) dimorphic fungi

4. Yeasts spherical or oval “budding”
1 yeast cell can produce up to 24 daughter cells by “budding”
short chain of cells

5. Molds
thallus (body)
hyphae
septa
septate hyphae

6. Dimorphic Fungi 2 forms of growth in pathogenic species
1) mold
2) yeast
Mold: hyphae (multicellular)
Yeast: buds (unicellular)

7. Dermatomycosis dermatophytes epidermis, hair, and nails
enzyme: keratinase
direct contact, infected hairs and epidermal cells
3 genera

8. Coccidioidomycosis
Readings question #1: What is coccidioidomycoses? What microorganism causes this disease and where is it found? How is it transmitted?
San Joaquin Fever

9. Diagnosis Spherules (spores) in tissues or fluids Tissues, lesions
Laboratory workers: infectious aerosols
Increasing in California and Arizona

10. Histoplasmosis
Readings question #2: What is the causative microorganism? Where is this microorganism found? How is the disease acquired?

11. Candidiasis Bacterial microbiota (genitourinary tract)
Antibacterial drugs
Normal mucosal pH
Readings question #3: What microorganisms cause candidiasis? How may this infection appear in infants? What is it called?

12. Cryptococcosis Spherical cells, budding Polysaccharide capsules
Soil, pigeon roosts and nests
Inhalation of dried droppings

13. Brain Tissue with Cavities

14. Aspergillosis
Readings question #4: What is the causative fungus? Where is it found? How is it spread? What are the symptoms for the disease?

15. Pneumocystis Pneumonia (PCP)
Healthy human lungs
High infection rate in general population
Lining of the alveoli
Diagnosis: sputum samples

16. Readings Question #5
How is the disease PCP spread? What are its symptoms? Is it potentially fatal? (If yes, how does death occur?)