1. A Focus on Polycythemia Vera for Nurse Practitioners and Physician Assistants

4. Polycythemia Vera

5. Case 1

6. Initial Workup for PV

7. WHO 2008 Diagnostic Criteria for PV

8. Treatment Goals

9. Risk Factors for Decreased Survival

10. Risk Stratification for Thrombosis in PV

11. Case 1 Laboratory Results

12. Risk-Adapted Treatment Strategy

13. Case 1 4 Years Later—Progressive Disease

14. Cytoreductive Therapy

15. Management of Disease Symptoms

16. Management of Treatment-Related AEs

17. Case 1: Follow-Up and Monitoring

18. Evaluating Response to Treatment

19. 3-Way Communication Is the Key to Continuity of Care

20. Case 1 10 Years Later—Progressive Disease

21. Resistance/Intolerance to HU

22. Treatment of HU-Resistant and Intolerant PV

23. Ruxolitinib

24. Mechanism of JAK-STAT Signaling

25. Ruxolitinib Efficacy RESPONSE Trial

26. Ruxolitinib Efficacy RESPONSE Trial (cont)

27. Ruxolitinib Dosing for PV

28. Ruxolitinib Dose Modifications

29. Ruxolitinib Safety Profile

30. Ruxolitinib Safety Profile Management

31. Case 1 Treatment Plan

32. Patient Communication and the Role of Caregivers

33. Abbreviations

34. Abbreviations (cont)