1. Managing CINV and Cachexia

2. Program Goals

3. Concepts and Definitions for “Supportive Care” and “Palliative Care”

4. Supportive Care and Palliative Care

5. Supportive Care and Palliative Care (cont)

6. Supportive Care and Palliative Care (cont)

7. Cancer-Related Cachexia

8. Definition and Classification of Cancer-Related Cachexia An International Consensus

9. New Avenues of Investigation for Treatment of Cancer-Related Cachexia

10. ROMANA 1 and ROMANA 2 Phase 3 Study Design

11. ROMANA 1 and ROMANA 2 Efficacy Results: Co-Primary End Points

12. ROMANA 1 and ROMANA 2 Efficacy and Safety

13. Rolapitant

14. Rolapitant (cont)

15. Rolapitant: Regional Differences Subgroup Analysis of HEC Study

16. NEPA

17. NEPA (cont)

18. NEPA + DEX: Overall CR Rate by Gender/Age Pooled Analysis of Patients Receiving HEC in 3 Pivotal Studies

19. NEPA: Maintenance of Control Over 4 Cycles Pooled Analysis From 2 Studies

20. NEPA

21. Aprepitant in Children Phase 3 Trial Design

22. Aprepitant in Children (cont) Efficacy and Safety

23. Palonosetron vs Ondansetron in Children Phase 3 Trial Design

24. Palonosetron vs Ondansetron in Children (cont) Efficacy and Safety

25. Summary

26. Abbreviations

27. Abbreviations (cont)

28. References

29. References (cont)

30. References (cont)

31. References (cont)

32. References (cont)

33. References (cont)

34. References (cont)