1. Kasteleijn-Nolst Trenité
E-Figure 1
Kasteleijn-Nolst Trenité
(A)
(B)
Dizziness 60 60
Dizziness
Somnolence
100
100 50 50 40 40 10 10
GBP
Photosensitivity window (Hz) 30
Plasma concentration (µg/mL)
Photosensitivity window (Hz) 30
Plasma concentration (µg/mL) 1 20 20 1 10 10
0.1
0.1
BRV
BRV
0.05
0.05 PD
0.5 1 2 4 6 8 PD
0.5 1 2 4 6 8 24 28 PD
0.5 1 2 4 6 8 PD
0.5 1 2 4 6 8 24 28
Placebo
Brivaracetam 10 mg
Placebo
Brivaracetam 20 mg
Sampling points (hour post-dose)
Sampling points (hour post-dose)
(C)
(D) 60 60
Dizziness
100
100 50 50 40 40 10 10
LTG
Photosensitivity window (Hz) 30
Plasma concentration (µg/mL)
Photosensitivity window (Hz) 30
Plasma concentration (µg/mL) 1 20 1 20 10 10
0.1
BRV
0.1
BRV
0.05
0.05 PD
0.5 1 2 4 6 8 PD
0.5 1 2 4 6 8 24 28 32 48 72 PD
0.5 1 2 4 6 8 PD
0.5 1 2 4 6 8 24 28 32 48 72
Placebo
Brivaracetam 40 mg
Placebo
Brivaracetam 80 mg
Sampling points (hour post-dose)
Sampling points (hour post-dose)