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Boosting Bacterial Metabolism to Combat Antibiotic Resistance

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1 Boosting Bacterial Metabolism to Combat Antibiotic Resistance
Prerna Bhargava, James J. Collins  Cell Metabolism  Volume 21, Issue 2, Pages (February 2015) DOI: /j.cmet Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Exogenous Addition of Metabolites Enhances Antibiotic Uptake, Leading to Cell Death (A) Antibiotic-resistant cells have lower metabolite abundances, leading to reduced PMF, inhibited drug uptake, and survival. (B) Exogenous addition of alanine and/or glucose can enhance drug uptake and restore cell sensitivity. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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