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Salvage Stereotactic Ablative Irradiation for Isolated Postsurgical Local Recurrence of Lung Cancer  Atsuya Takeda, MD, PhD, Naoko Sanuki, MD, Takahisa.

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Presentation on theme: "Salvage Stereotactic Ablative Irradiation for Isolated Postsurgical Local Recurrence of Lung Cancer  Atsuya Takeda, MD, PhD, Naoko Sanuki, MD, Takahisa."— Presentation transcript:

1 Salvage Stereotactic Ablative Irradiation for Isolated Postsurgical Local Recurrence of Lung Cancer 
Atsuya Takeda, MD, PhD, Naoko Sanuki, MD, Takahisa Eriguchi, MD, Tatsuji Enomoto, MD, PhD, Tetsuya Yokosuka, MD, Takeshi Kaneko, MD, PhD, Hiroshi Handa, MD, PhD, Yousuke Aoki, RTT, Yohei Oku, PhD, Etsuo Kunieda, MD, PhD  The Annals of Thoracic Surgery  Volume 96, Issue 5, Pages (November 2013) DOI: /j.athoracsur Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Staple line recurrence adjacent to the right pulmonary artery and superior vena cava. (A) Pretreatment axial computed tomography images show dose distribution curve. The bold isodose lines from outer to inner represent 10, 20, 30, 40, and 50 Gy, respectively. For the planning target volume surface, a total dose of 40 Gy per 5 fractions (60% isodose) was administered. (B) Axial computed tomography images 1 year after stereotactic ablative body radiotherapy show that the recurrent lesion was vanishing and became a scar-like shadow. (C) 2-Dexoy-2-18F-fluoro-D-glucose–positron-emission tomography/computed tomography image 1 year after stereotactic ablative body radiotherapy shows that the maximum standardized uptake value decreased from 3.4 at the pretreatment study to 2.2. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Staple line recurrence invading into the aortic arch. Pretreatment (A) coronal and (B) axial computed tomography images show the dose distribution curve. The bold isodose lines from outer to inner represent 12.5, 25, 37.5, 50, and 62.5 Gy, respectively. For the planning target volume surface, a total dose of 50 Gy per 10 fractions (80% isodose) was administered. (C) Axial computed tomography image 3 years after stereotactic ablative body radiotherapy clearly shows that the recurrence disappeared. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) Local control rates were 94.7% at 1 year and 86.8% at 2 years. (B) Overall survival rates were 84.0% at 1 year and 76.4% at 2 years. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Bronchial stenosis is shown within the planning target volume. (A) Pretreatment axial computed tomography image shows dose distribution. The bold isodose lines from outer to inner represent 10, 20, 30, 40, and 50 Gy, respectively. For the planning target volume surface, a total dose of 40 Gy per 5 fractions (60% isodose) was administered. The right main bronchus was included in the planning target volume surface; therefore, more than 40 Gy per 5 fractions was irradiated to the right main bronchus. (B) The 2-dexoy-2-18F-fluoro-D-glucose–positron-emission tomography/computed tomography image 2 years after stereotactic ablative body radiotherapy shows the maximum standardized uptake value decreased from 3.0 at pretreatment study to 2.2. (C and D) Axial computed tomography images 3.5 years after stereotactic ablative body radiotherapy show consolidation and bronchial stenosis. The consolidation has no change during the late 2 years and is regarded as no recurrence. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

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