1. Title: What is Acylation?
Saturday, 01 December 2018
Title: What is Acylation? 1
Looking at the worksheet on Acylation, read through the introduction and example 1 and 2.
Attempt Example 3 and 4.
Classroom expectations Arrive on time Coat off Bags off desks Planner on desk Equipment on desk

2. Saturday, 01 December 2018

3. ACYLATION Acylation = replacing an H with an acyl group
Acyl group from
acyl chloride
Acyl group
acid anhydride
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4. ACYLATION Acylation = replacing an H with an acyl group
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5. ACYLATION Acylation = replacing an H with an acyl group
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6. ACYLATION Acylation = replacing an H with an acyl group
e.g. ethanol + propanoyl chloride
e.g. methylamine + ethanoic anhydride
© A June-2016

7. ACYLATION Acylation = replacing an H with an acyl group
e.g. water + propanoyl chloride
e.g. ammonia + ethanoyl chloride
© A June-2016

9. ACYLATION Acylation = replacing an H with an acyl group
e.g. propan-2-ol + ethanoyl chloride
e.g. ethylamine + propanoic anhydride
© A June-2016

10. ACYLATION Acylation = replacing an H with an acyl group
e.g. propylamine + butanoyl chloride
e.g. propan-1-ol + ethanoic anhydride
© A June-2016

11. ACYLATION Acylation = replacing an H with an acyl group
e.g. water + butanoic anhydride
e.g. ammonia + propanoic anhydride
© A June-2016

12. ACYLATION Nucleophilic addition-elimination alcohols & water
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13. ACYLATION Nucleophilic addition-elimination amines & ammonia
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14. ACYLATION Nucleophilic addition-elimination
e.g. ethanol + propanoyl chloride
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15. ACYLATION Nucleophilic addition-elimination
e.g. ammonia + ethanoyl chloride
© A June-2016

16. ACYLATION Nucleophilic addition-elimination
e.g water + propanoyl chloride
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17. ACYLATION Nucleophilic addition-elimination
e.g. propan-2-ol + ethanoyl chloride
© A June-2016

18. ACYLATION Nucleophilic addition-elimination
e.g. propylamine + butanoyl chloride
© A June-2016