1. Phosphorylation and sequence disorder in microtubule-associated protein Tau.A, schematic illustration of the domain profile of Tau with all known phosphorylation sites and phosphorylation sites characterized in this study (red).
Phosphorylation and sequence disorder in microtubule-associated protein Tau.A, schematic illustration of the domain profile of Tau with all known phosphorylation sites and phosphorylation sites characterized in this study (red). The majority of phosphorylation sites cluster on either side of the four tubulin-binding domains in Tau protein. B, disorder plot of Tau that shows that the regions of disorder map to the regions on either side of the tubulin-binding domains where the majority of phosphorylation sites lie.
Mark O. Collins et al. Mol Cell Proteomics 2008;7:
© 2008 The American Society for Biochemistry and Molecular Biology