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Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

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Presentation on theme: "Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling"— Presentation transcript:

1 Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling
Jun Takatoh, Fan Wang  Neuron  Volume 74, Issue 1, Pages 3-5 (April 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Target- and Pathway-Derived BDNF through TrkB Signaling Stimulates the Translation of SMAD1/5/8 in the Axons and Growth Cones of TG Sensory Neurons in the Op and Mx but Not the Md Branches Op and Mx target-derived BMP4 binds BMP receptors and induces the formation of retrograde signaling endosomes in TG neurons. The BMP signaling endosomes require axonally synthesized SMADs to elicit transcriptional changes such as induction of Tbx3 gene. Neuron  , 3-5DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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