1. Figure 4 Osteocyte regulation of bone formation and resorption
Figure 4 | Osteocyte regulation of bone formation and resorption. Osteocytes produce and secrete molecules that stimulate or inhibit osteoclast or osteoblast differentiation, viability and function. Osteoclast differentiation and survival are modulated by osteocyte-derived pro-osteoclastogenic cytokines RANKL and M‑CSF and the anti-osteoclastogenic cytokine OPG. Osteoblast generation, survival and function is regulated by osteocyte-derived antagonists of Wnt/β‑catenin signalling and by proteins regulators of matrix mineralization. DKK‑1, Dickkopf-related protein 1; DMP‑1, dentin matrix acidic phosphoprotein 1; FGF23, fibroblast growth factor 23; M‑CSF, macrophage colony-stimulating factor; MEPE, matrix extracellular phosphoglycoprotein; OPG, osteoprotegerin; PHEX, phosphate-regulating neutral endopeptidase; RANKL, receptor activator of nuclear factor‑κB ligand; SFRP‑1, secreted frizzled-related protein 1.
Plotkin, L. I. & Bellido, T. (2016) Osteocytic signalling pathways as therapeutic targets for bone fragility
Nat. Rev. Endocrinol. doi: /nrendo