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Adipocytes at the Core of Bone Function

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1 Adipocytes at the Core of Bone Function
Gerald Grandl, Christian Wolfrum  Cell Stem Cell  Volume 20, Issue 6, Pages (June 2017) DOI: /j.stem Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Adipose Precursor Hierarchy in the Bone Marrow
Multipotent CD45– CD31– Sca1+ CD24+ precursors (top) increase hematopoietic niche function and give rise to CD45– CD31– Sca1– PDGRFα+ osteogenic and CD45– CD31– Sca1+ CD24– adipogenic precursors, which can differentiate into CD45– CD31– Sca1– Zfp234+ preadipocytes and mature marrow adipocytes. Both adipogenic precursors and mature adipocytes decrease hematopoietic niche functionality and bone mineralization/healing potential. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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