1. Kidney Macrophages: Unique Position Solves a Complex Problem
Miriam Berry, Menna R. Clatworthy 
Cell 
Volume 166, Issue 4, Pages (August 2016)
DOI: /j.cell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Tissue Macrophage Location Determines Access to Circulating Antigens
Macrophages in different organs have variable access to circulating antigens, including immune complexes (IC). Kupffer cells in the liver and red pulp macrophages in the spleen are situated in direct continuity with the circulation and provide the major disposal mechanism for circulating IC. Dermal macrophages and alveolar macrophages are separated from the vasculature via a non-fenestrated basement membrane (orange line) and therefore do not take up and are not activated by, circulating IC. Kidney macrophages form a functional unit with endothelial cells, rapidly taking up IC transported to them by virtue of their unique position and morphology.
Cell  , DOI: ( /j.cell )
Copyright © 2016 Elsevier Inc. Terms and Conditions