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Volume 150, Issue 4, Pages e1 (April 2016)

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1 Volume 150, Issue 4, Pages 854-865.e1 (April 2016)
Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study  Leo Alexandre, Allan B. Clark, Hina Y. Bhutta, Simon S.M. Chan, Michael P.N. Lewis, Andrew R. Hart  Gastroenterology  Volume 150, Issue 4, Pages e1 (April 2016) DOI: /j.gastro Copyright © 2016 AGA Institute Terms and Conditions

2 Figure 1 Flow chart of study participants.
Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions

3 Figure 2 Adjusted time-dependent Cox proportional hazard regression survival curves with hazard ratios for esophageal cancer–specific mortality stratified according to postdiagnosis statin use. (A) Total esophageal carcinoma cases linked to NCR (N = 1222). (B) Esophageal adenocarcinoma (n = 470). (C) Esophagogastric junctional adenocarcinoma (n = 184). (D) Esophageal squamous cell carcinoma (n = 267). All adjusted for age, sex, body mass index, smoking status, cardiovascular diseases, diabetes, surgery, prediagnosis statin use, postdiagnosis use of aspirin, beta-blockers, angiotensin–converting enzyme inhibitors/angiotensin-receptor blockers, and nonsteroidal anti-inflammatory drugs. Only cases with complete body mass index and smoking data were included. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions

4 Figure 3 Adjusted time-dependent Cox proportional hazard regression survival curves with hazard ratios for all-cause mortality stratified according to postdiagnosis statin use. (A) Total esophageal carcinoma cases (N = 3595). (B) Esophageal adenocarcinoma (n = 470). (C) Esophagogastric junctional adenocarcinoma (n = 184). (D) Esophageal squamous cell carcinoma (n = 267). (A) Adjusted for age, sex, body mass index, smoking status, cardiovascular diseases, diabetes, prediagnosis statin use, postdiagnosis use of aspirin, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers, and nonsteroidal anti-inflammatory drugs. (B–D) Adjusted for the earlier-listed factors including surgery. Only cases with complete body mass index and smoking data were included. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Kaplan-Meier plot of time to first statin prescription from diagnosis of EC amongst postdiagnosis statin users in the whole cohort (n = 830). Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions


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