1. Department of Biomedical Informatics, The Ohio State university
Dysregulated expression of glucose metabolic enzymes is associated with poor prognosis of patients with hepatocellular carcinoma
Xiaoli Zhang, PhD.
Department of Biomedical Informatics, The Ohio State university

2. Introduction
Liver cancer is the second leading cause of cancer related death worldwide because of limited therapeutic options, where hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases. It is highly malignant, recurrent, drug resistant, and often diagnosed at the advanced stage.
The enzymes within the glucose metabolic pathways have been shown to be essential for the growth and survival of cancer cells. The accelerated aerobic glycolysis in tumor has been considered one of the hallmarks that distinguish cancer cells from normal cells.
Liver cancer cells reprogram their metabolic pathways to meet their needs for rapid proliferation and generation of the biomass for tumor growth.

3. Objective
Using liver hepatocellular cancer dataset of the Cancer Genome Atlas (LIHC TCGA) to investigate
how the expression of genes in glucose metabolic pathways are altered
how the alterations are associated with patient clinical stage, overall survival, and recurrence free survival in liver cancer
with the ultimate goal to identify biomarkers for the development of personized medicine to treat liver cancer.

5. Dysregulated expression of glucose metabolic enzymes is associated with poor prognosis of HCC patients

6. Red: upregulated exp in tumor. Green: downregulated exp in tumor.
F2,6 BP
G6P
F6P
F1,6BP
PEP
DHAP
1,3BPG
G3P
3PG
2PG
pyruvate
lactate
succinate
Fumarate
Malate
OAA
AcCoA
Citrate
Cis-Aconitate
D-isocitrate
α-KG
Succiny-CoA
glucose
LDHA
LDHD
SLC2A2, SLC2A3, SLC2A5
GCK, HK3
ALDOA, ALDOB, ALDOC
PGK1
PGAM2
ENO1,ENO3
PKM2
PFKFB1, PFKFB2,
PFKFB3, PFKFB4
FAS
ACLY
ACO1 CS
IDH2
SUCLG2
SDHA,SDHB,SDHD
PCK1,PCK2
SLC16A1, SLC16A3,
SLC16A4, SLC16A7
G1P
PGM1 PC
2,3BPG
BPGM
Red: upregulated exp in tumor.
Green: downregulated exp in tumor.
Bold: independent predictors for OS

7. More information please stop by
poster session # at 10:30AM.
Thank you!!