1. Genome organization and Bioinformatics
BI420 – Introduction to Bioinformatics
Genome organization and Bioinformatics
Gabor T. Marth
Department of Biology, Boston College

2. The animal cell

3. DNA – the carrier of the genetic code

4. DNA organization – chromosomes

5. DNA organization – mitochondria

6. Translation of genetic information

7. Gene organization

8. mRNA splicing – alternative splicing

9. Gene expression

10. Protein structure

11. RNA structure

12. DNA evolution

13. Mechanisms of molecular evolution

14. Evolution of chromosome organization

15. Evolution of gene structure

16. Evolution of DNA sequence

17. Genetic variations

18. 1. DNA sequencing informatics

19. 2. Gene prediction, genome annotation

20. De novo gene prediction

21. Repeat masking

22. 3. Similarity searching

23. 4. Gene localization – genetic mapping

24. Genetic mapping

25. Genetic mapping
0.4 cm
1.3 cm
0.7 cm
0.4 Mb
0.7 Mb
0.3 Mb

26. 5. Polymorphism discovery and analysis
look at multiple sequences from the same genome region
use base quality values to decide if mismatches are true polymorphisms or sequencing errors

27. 6. Gene function – expression analysis

28. 7. Evolutionary analysis – phylogenetics

29. Gene evolution

30. Genome evolution

31. 8. Protein structure prediction
+ computational predictions based on measurements

32. 9. RNA structure prediction