1. Plasma Clearance

5. Plasma Clearance
Is the volume of plasma that is completely cleared of the substance by the kidneys per unit time.

6. Clearance rate of a substance (ml/min) = U x V P
Urine conc. of the substance x Urine flow rate (ml/min)
__________________________________________________
Plasma concentration of the substance per ml of plasma

9. = U x V P 5.85mg/ml x 1ml/min 0.01mg/ml = 585 ml/min Extraction ratio for PAH is 90% 585ml/min/0.9 = 650ml/min Total blood flow through kidneys= 650/( )= 1185 ml/min