1. Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.74
Figure 1 Interaction between PNPLA3 genotype and BMI influences the severity of NAFLD
Figure 1 | Interaction between PNPLA3 genotype and BMI influences the severity of NAFLD. As reported by Stender et al.2, the magnitude of the genetic contribution to hepatic triglyceride content and risk of NAFLD-associated cirrhosis is accentuated in a stepwise fashion as BMI increases. The size of the brown arrows depicts the magnitude of the genetic contribution to the variation in hepatic lipid accumulation and risk of NAFLD progression to liver cirrhosis with patatin-like phospholipase domain-containing 3 (PNPLA3) genotype and BMI (kg/m2). Homozygous carriage of the PNPLA3 rs M variant ( C>G, encoding PNPLA3-I148M) polymorphism (MM) exerts the greatest effect on NAFLD severity in patients in the highest BMI category. Individuals with a high BMI who are homozygous for wild-type PNPLA3 (II), or who are heterozygous for PNPLA3 M variant (IM), have a lower risk of NAFLD progression.
Mann, J. P. & Anstee, Q. M. (2017) PNPLA3 and obesity: a synergistic relationship in NAFLD
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