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Out With the Old and In With the New, Again?

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Presentation on theme: "Out With the Old and In With the New, Again?"— Presentation transcript:

1 Out With the Old and In With the New, Again?

2 Out With the Old, In With the New

3 Current Standard of Care

4 NEUTRINO and FISSION SOF + RBV ± pegIFN for Treatment-naive Patients

5 NEUTRINO and FISSION SOF + RBV ± pegIFN for Treatment-naive Patients

6 FUSION SOF + RBV ± pegIFN in Treatment-experienced Patients With G2,3 HCV

7 VALENCE SOF + RBV for 12 Weeks or 24 Weeks in G2 or G3 HCV Infection

8 QUEST 1 and 2 Q80K Variant Adversely Affects SVR12 of SMV-based Therapy

9 COSMOS SOF + SIM ± RBV for G1 HCV-infected Patients by Fibrosis Stage

10 2014 AASLD HCV Treatment Guidelines

11 ION-1 On the Road to IFN-free Therapy for G1 HCV Infection

12 ION-3 8 Weeks or 12 Weeks of SOF/LDV for Treatment-naive G1 HCV Infection

13 ION-2 SOF/LDV in G1 HCV-infected Patients Failing PegIFN/RBV ± DAA

14 HALLMARK-DUAL Phase 3 Trial of the All-oral Regimen DCV + ASV for G1b HCV Infection

15 SAPPHIRE I ABT-450/r/Ombitasvir + Dasabuvir (3D) + RBV for G1 HCV Infection

16 SAPPHIRE II ABT-450/r/Ombitasvir + Dasabuvir + RBV (3D) G1 HCV

17 TURQUOISE II ABT-450/r/Ombitasvir + Dasabuvir (3D) + RBV in Cirrhosis

18 The Past And Future of HCV Therapy

19 Abbreviations

20 Abbreviations (cont)

21 Abbreviations (cont)

22 References

23 References (cont)

24 References (cont)

25 References (cont)


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