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Jagadeesh Bayry, Jean-François Gautier  Cell Metabolism 

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Presentation on theme: "Jagadeesh Bayry, Jean-François Gautier  Cell Metabolism "— Presentation transcript:

1 Regulatory T Cell Immunotherapy for Type 1 Diabetes: A Step Closer to Success? 
Jagadeesh Bayry, Jean-François Gautier  Cell Metabolism  Volume 23, Issue 2, Pages (February 2016) DOI: /j.cmet Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Scheme of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cell Therapy in Adult Type 1 Diabetes Bluestone et al. (2015) collected 400 ml of blood from patients with recent-onset adult T1D. CD4+CD25+CD127lo regulatory T cells (Tregs) were sorted and expanded for 14 days. Following detailed analysis of expanded Tregs, patients received a single dose of Tregs. During the follow up, patients were assessed for safety and immunological and metabolic parameters. Tracking of adoptively transferred Tregs was also performed. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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