Download presentation
Presentation is loading. Please wait.
Published byJulia Richard Modified over 6 years ago
1
Lyme borreliosis: from infection to autoimmunity
S.K. Singh, H.J. Girschick Clinical Microbiology and Infection Volume 10, Issue 7, Pages (July 2004) DOI: /j x Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
2
Fig. 1 Transmission electronmicrograph of Borrelia burgdorferi strain sensu strictu showing the corkscrew shape and motility, and the outer-membrane surrounding a periplasmic space that contains the variable number of flagella and the protoplasmic cylinder. Insert: Immuno-electronmicrograph using a polyclonal antiserum against Borrelia burgdorferi, demonstrating that a bleb formed during in-vitro culture is an integral part of the bacterial cell. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
3
Fig. 2 Transmission electronmicrograph of a human synovial cell infected with Borrelia burgdorferi in vitro, demonstrating an intracellular cytosolic location of the spirochaetes, identified by multiple corkscrew-shaped structures in the cytosol. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
4
Fig. 3 Transmission electronmicrograph of a human peripheral blood monocyte, showing conventional phagocytosis of a Borrelia burgdorferi strain sensu strictu in a large central and smaller phagolysosome at the bottom of the figure. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
5
Fig. 4 Molecular mimicry in Lyme arthritis, depicting antigen-presenting cells (in this case monocytes, macrophages, dendritic cells and synovial fibroblasts) presenting peptides generated from borrelial OspA and host LFA-Ia (human leucocyte function-associated antigen 1), which induce a cross-reactive T-cell response. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
6
Fig. 5 Coiling phagocytosis of Borrelia burgdorferi by a cluster of human peripheral blood monocytes with their borders outlined in the scheme. The central cell shows multiple coiling phagocytosis figures probably trying to engulf one single spirochaete. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions
Similar presentations
© 2024 SlidePlayer.com. Inc.
All rights reserved.