1. Keratometric Changes in Noninflammatory Corneal Ectasic Diseases After Intraocular Pressure Reduction
Authors has no financial interest.
Renata T Kashiwabuchi, Camila Gadelha, Wilson de Freitas, Carlos Arce, Mauro Campos
Federal University of Sao Paulo, Paulista School of Medicine – Sao Paulo, Brasil

2. Purpose: To assess possible keratometric changes after intra-ocular pressure reduction and describe any change observed.

3. Methods
Ten patients: 9 bilateral keratoconus and 1 corneal ectasia after refractive procedure.
All patients were submitted to the follow exams before and after intra-ocular pressure reduction:
Corneal Analysis System EyeSy (EyeSys Laboratories Incorporation, Houston, Texas, USA),
Pentacam (Oculus, Wetzlar, Germany),
Corneo-Gage Plus (Sonogage, Cleveland, OH),
Galilei (Zymer, SMT Swiss Microtechnology AG, Port, Switzerland)
Ocular Respose Analyser (ORA; Reichert Ophthalmic Instruments, Depew, NY),
Intra-ocular pressure was measured by Goldman applanation tonometer in 90 and 180 axes by examiner 1 as well as all exams.

4. Methods
For each patient one eye was assigned randomly to receive hypotensive drugs. Instructions about the drops were given to the patients by examiner 2.
Examiner 1 has no access to details of random process.

5. Results (table)
Significant differences were observed in the follow data (hypotensive group):
PIO (Goldman) = 5.45 ± 2.3 mmHg (p=0.00),
Pentacan
Anterior Chamber Depth= 3.5 ± 0.3 µm (p = 0.04)
Anterior Chamber Volume= 218 ± mm3 (p= 0.004),
ORA data:
IOPcc= 8.1 ± 3.1 mmHg (p= 0.00),
IOPg= 4.75 ± 2.1mmHg (p= 0.00)
CRF= 6.0 ± 0.4 (p= 0.01).

6. Results (abbreviation)
IOP (Goldman)= Intra ocular pressure assessed by Goldman Tonometry
Km =mean simulated K power
P= Pentacan
Km post = posterior corneal power
ACV = Anterior Chamber Volume
ACD = Anterior Chamber Depth
G = Galilei
IOPcc = Corneal Compensated Intra Ocular Pressure
IOPg = Goldman Compensated Intra Ocular Pressure
CRF = Corneal Resistance Factor
CH = Corneal Histeresis

7. Before After PIO (Goldman) Km (EyeSys) Km (P) Km post (P) ACV ACD
11.9 ± 2.3 mmHg
5.4 ± 2.3 mmHg
Km (EyeSys)
Km= 47.6 ± 6.6
47.4 ± 6.3
Km (P)
42.9 ± 14.8
46.8 ± 4.8
Km post (P)
-5.5 ± 4.6
-6.9 ± 0.8
ACV
229.9 ± mm3
218.9 ± mm3
ACD
46.84 ± 4.8 µm
Km (G)
49.9 ± 7.4
49.7 ± 7.3
Km post (G)
-7.5 ± 1.2
-7.4 ± 1.2
IOPcc
15.2 ± 5.8 mmHg
8.1 ± 3.1mmHg
IOPg
12.5 ± 3.6 mmHg
4.7 ± 2.1 mmHg
CRF
8.1 ± 1.0 mmHg
6.0± 0.4 mmHg CH
8.7 ± 2.5 mmHg
9.1 ± 1.2 mmHg
Data from hypotensive group

8. Conclusion: Even though a significant intra-ocular pressure reduction no keratometry changes were observed in no device used.