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Genes governing premature ovarian failure

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Presentation on theme: "Genes governing premature ovarian failure"— Presentation transcript:

1 Genes governing premature ovarian failure
Hridesh Dixit, Lakshmi Rao, Venkata Padmalatha, Turlapati Raseswari, Anil Kumar Kapu, Bineet Panda, Kanakavalli Murthy, Durgadutta Tosh, Pratibha Nallari, Mamata Deenadayal, Nalini Gupta, Baidyanath Chakrabarthy, Lalji Singh  Reproductive BioMedicine Online  Volume 20, Issue 6, Pages (June 2010) DOI: /j.rbmo Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Germ cell attrition and follicular atresia according to Kaipia and Hsueh (1997). Germ cells migrate to the ovary during early embryonic development. Their number increases through mitotic divisions but most of the oocytes formed during development do not survive to the time of birth. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Classification of follicles in the human ovary. Growing follicles enter class 2 usually in the late luteal phase, class 3 between late luteal and early follicular phases, class 4 during late follicular phase and become recruitable class 5 follicles during late luteal phase. GC=granulosa cells; TIC=theca interna cells. From Gougeon (1996). Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

4 Figure 3 The pathway representing candidate genes of ovarian failure involved in FSH regulation. ALK4=activin receptor-like kinase 4; BMP15=bone morphogenetic protein 15; GDF9=growth differentiation factor 9. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

5 Figure 4 Detailed presentation of inhibin and activin receptor system on gonadotroph cells. ActRIIA/B=activin type II receptor; ALK4=activin receptor-like kinase 4. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions


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