1. Epistatic interactions and gene expression variation.
Epistatic interactions and gene expression variation. (A) Schematic representation of three classes of epistatic interactions. Epistatic interactions can occur when two genes are mutated (genetic–genetic interaction), when one gene is mutated and the other gene varies in expression (genetic–epigenetic interaction), or when two genes simultaneously vary in expression (epigenetic–epigenetic interaction). (B) The more potential epistatic interaction partners a gene has, the more its expression variation should be constrained during evolution.
Solip Park, and Ben Lehner Mol Syst Biol 2013;9:645
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