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Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David.

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Presentation on theme: "Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David."— Presentation transcript:

1 Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma  Patrick Booms, MSca, David Cheung, MDa, Mieke C. Timmers, a, Aeilko H. Zwinderman, PhD b, Peter J. Sterk, PhDa  Journal of Allergy and Clinical Immunology  Volume 99, Issue 3, Pages (March 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 FIG. 1 Average dose-response curves to inhaled methacholine in the placebo-treated group (left) and in the budesonide-treated group (right) at week 0 (entry, continuous lines ) and week 12 (end of treatment period, dotted lines). Data points have been included if more than 50% of patients inhaled the plotted methacholine dose. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 FIG. 2 Percentage of patients exhibiting a maximal-response plateau on the dose-response curve of FEV1 to inhaled methacholine in placebo and budesonide groups during run-in, treatment, and washout periods. Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 FIG. 3 Geometric mean values (±SEM in 2log values; doubling doses) of PC20 before, during, and after treatment with placebo (open symbols) or inhaled budesonide (closed symbols). Journal of Allergy and Clinical Immunology  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions


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