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Sequence analyses and evolutionary conservation of the CLDN10 gene and the identified CLDN10 variants. Sequence analyses and evolutionary conservation.

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Presentation on theme: "Sequence analyses and evolutionary conservation of the CLDN10 gene and the identified CLDN10 variants. Sequence analyses and evolutionary conservation."— Presentation transcript:

1 Sequence analyses and evolutionary conservation of the CLDN10 gene and the identified CLDN10 variants. Sequence analyses and evolutionary conservation of the CLDN10 gene and the identified CLDN10 variants. (A) Genomic structure of the human CLDN10 gene located at chromosome 13. (B) Schematic representation of the CLDN10 cDNA on the basis of the longest protein coding sequence (NM_ ). CLDN10 variants are depicted by vertical lines indicating the cDNA position and describing the effect on protein level. (C) Chromatograms for the different mutations confirmed by Sanger sequencing. (D) Evolutionary conservation of Asp73 and Pro149. The third CLDN10 variant is predicted to induce an alternative splice site leading to loss of glutamic acid at position 157 to tyrosine at position 192 and therefore, not depicted. (E) Predicted topology of the Claudin-10 protein with location of the different mutations and deletion indicated. TM, transmembrane region. Ernie M.H.F. Bongers et al. JASN 2017;28: ©2017 by American Society of Nephrology

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