1. Improving Risk Assessment and Early Diagnosis in PAH

2. Program Themes

3. Initial Presentation

4. Initial Presentation (cont)

5. Physical Exam

6. Physical Exam (cont)

7. Physical Exam (cont)

8. Evaluation of Findings

9. Test Results: Echo (May 2015)

10. What Else Can Be Learned From Echo?

11. Additional Diagnostics

12. RHC Results

13. Determinants of Prognosis in PAH

14. Therapies Based on Risk

15. Initial Therapy

16. Clinical Efficacy/Safety AMBITION Trial

17. Evolving Approach to Combination Therapy

18. Follow-Up Visit (September 2015)

19. Echo (March 2016)

20. RHC Results: Hemodynamics

21. Clinical Follow-Up + Objective Evaluation

22. 5th World Symposium on PH Goals of Therapy: Setting the Bar Higher

23. Clinical Efficacy/Safety GRIPHON Trial

24. GRIPHON: Treatment Effect by Subgroup

25. Conclusions

26. Abbreviations

27. Abbreviations (cont)

28. Abbreviations (cont)