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Volume 55, Issue 6, Pages (June 2009)

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1 Volume 55, Issue 6, Pages 1386-1396 (June 2009)
Bladder Tumor Infiltrating Mature Dendritic Cells and Macrophages as Predictors of Response to Bacillus Calmette-Guérin Immunotherapy  Cherifa Ayari, Hélène LaRue, Hélène Hovington, Marc Decobert, François Harel, Alain Bergeron, Bernard Têtu, Louis Lacombe, Yves Fradet  European Urology  Volume 55, Issue 6, Pages (June 2009) DOI: /j.eururo Copyright © 2009 European Association of Urology Terms and Conditions

2 Fig. 1 (a–d) Immunohistochemistry (IHC) detection of mature CD83+ dendritic cells on bladder tumor sections; note infiltration in lymphoid aggregate (a and c), in the papillary axis (b), and in the underlying stroma (d). (e–h) IHC detection of expression of CD68 on bladder tumor sections: note infiltration in the stroma (e and h), in a lymphoid aggregate (f), and in the tumor (e, g, and h), and expression of CD68 by tumor cells (e and g). Microscopic field: ×10, except for d and g at ×20. European Urology  , DOI: ( /j.eururo ) Copyright © 2009 European Association of Urology Terms and Conditions

3 Fig. 2 Kaplan-Meier analysis of recurrence-free survival according to the number of cycles of maintenance bacillus Calmette-Guérin (BCG; no or one cycle compared with more than one cycle) for patients presenting (a) a low score or (b) a high score of tumor infiltration by CD83+ dendritic cells. European Urology  , DOI: ( /j.eururo ) Copyright © 2009 European Association of Urology Terms and Conditions

4 Fig. 3 Kaplan-Meier analysis of recurrence-free survival according to (a) the level of tumor infiltration by CD68+ macrophages, (b) the expression of CD68 in tumor cells, or (c) the combination of both. European Urology  , DOI: ( /j.eururo ) Copyright © 2009 European Association of Urology Terms and Conditions


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