1. Immunity-related genes and enhancers are enriched for eQTLs.
Immunity-related genes and enhancers are enriched for eQTLs. (A) GO enrichment using eGenes for the sarcoma cancer type. BP, biological process; CC, cellular component; MF, molecular function. (B and C) Quantile-quantile plots showing the deviation of SNP-gene pair association P values from the distribution expected under the null hypothesis (red line). (B) BLCA SNP-gene pair P values for SNPs located within either general (i.e., bladder tissue) (black) or immune (i.e., T cell) enhancer regions (blue). Relative to SNPs located within general enhancers, SNPs located within immune enhancers have more significant gene-SNP pair P values. (C) LUAD SNP-gene pair P values for SNPs located within either general (i.e., lung tissue) (black) or immune (i.e., T cell) enhancer regions (blue).
Yoong Wearn Lim et al. PNAS doi: /pnas
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