1. Figure S1. Distributions of scales for loneliness
Among all populations (10,760) Among European Americans (7,556 )
r1vs2 = 0.57, p<10-30
r1vs3 = 0.51, p<10-30
r2vs3 = 0.65, p<10-30
r1vs2 = 0.57, p<10-30
r1vs3 = 0.51, p<10-30
r2vs3 = 0.64, p<10-30
7064
5967
6263
4473
4556
3815
3640
2993
2587
2379
2049
1153
703
682
425
704
413

2. Figure S2. Distributions of summed loneliness scales (3-9)
For the Case: Control definition, those scored 4 and 5 were set as missing values

3. Figure S3. Race classified by PC1/PC2 and Self-reported Ethnicity
x self-reported EA
● self-reported AA
o self-reported Hispanic
◊ self-reported other
PC1
PC2

4. Figure S4. GWAS for Linear Mixed Models in imputed data using all 10,760 subjects
Linear trait (N= 10,760)
λ=1.02
λ1000 =1.00

5. Figure S5. GWAS for Multivariate Linear Mixed Models in imputed data using all 10,760 subjects
Multivariate (N= 10,760)
λ=1.00
λ1000 =1.00

6. Figure S6. GWAS for Case: Control analysis in imputed data using all 7,436 Case:Control subjects
Case:Control (N= 7,436)
λ=1.02
λ1000 =1.00