1. Killing effect of nanoencapsulated colistin sulfate on Pseudomonas aeruginosa from cystic fibrosis patients 
E. Sans-Serramitjana, E. Fusté, B. Martínez-Garriga, A. Merlos, M. Pastor, J.L. Pedraz, A. Esquisabel, D. Bachiller, T. Vinuesa, M. Viñas 
Journal of Cystic Fibrosis 
Volume 15, Issue 5, Pages (September 2016)
DOI: /j.jcf
Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

2. Fig. 1
Effect of free colistin, NLC of colistin, and mixtures of empty nanoparticles and free colistin on P. aeruginosa growth. (a) 056SJD at 1/4× MIC (0.5μg/mL); (b) 056SJD at MIC (2μg/mL); (c) 056SJD at 8× MIC (16μg/mL); (d) P19 at 1/4× MIC (8μg/mL); (e) P19 at MIC (32μg/mL), and (f) P19 at 8x MIC (256μg/mL). All incubations were at 37°C with shaking at 2000rpm and bacteria were in the exponential phase of growth.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

3. Fig. 2
AFM images obtained at 7μm2 of scan size of (a) untreated P. aeruginosa biofilms; (b) after treatment with 128μg/mL of free (first row) and nanoencapsulated (second row) colistin sulfate at 2h; (c) after treatment with 128μg/mL of free (first row) and nanoencapsulated (second row) colistin sulfate at 6h; (d) after treatment with 128μg/mL of free (first row) and nanoencapsulated (second row) colistin sulfate at 24h. First column shows topography images, whereas amplitude images are shown in second column.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

4. Fig. 3
Graphical representation of surface roughness (Ra) in nanometers, according to the different formulations tested and surface scans. Bars represent the standard deviation of the mean.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

5. Fig. 4
Typical force–distance curves of untreated and colistin and NLC-colistin-treated P. aeruginosa 056SJD.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf )
Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions