1. Joint Science Department
Claremont McKenna College ♦ Pitzer College ♦ Scripps College
Members of the Claremont Colleges J S D
Investigation of Catalytic Methods for the Preparation of N-Heterocycles
Anna G. Wenzel; W.M. Keck Science Center, Claremont CA 91711
A catalytic method for the preparation of dihydroquinolines utilizing copper triflate:
Air- and moisture-tolerant
Substrate scope extends to both aryl and aliphatic electrophiles
Reaction selective for N-acyl pyrroles (e.g. 2b favored over 2a)
Electronic tuning of the carbamate in 1 critical for nucleophilicity
Methodology a lead discovery point for new Brønsted acid catalysts