1. Trapping Small Caffeine in a Large GPCR Pocket
Fei Xu, Raymond C. Stevens 
Structure 
Volume 19, Issue 9, Pages (September 2011)
DOI: /j.str
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2. Figure 1
Illustration of the A2A Adenosine Receptor Structure and the Different Ligands Used in Revealing Its Binding Landscape
Employing some artistic creativity, the ligand binding site of the A2A adenosine receptor (brownish-gray structure) resembles a champagne flute in the cell membrane, with its tall narrow glass bowl facing the extracellular side and big flat foot inside of the membrane connected by a long stem. Binding of different types of ligands in the receptor cavity (the glass bowl) may induce different structural transformation signals that travel through the transmembrane domain (the stem) and impose amplified conformational changes at the intracellular interface (the foot).
Structure  , DOI: ( /j.str )
Copyright © 2011 Elsevier Ltd Terms and Conditions