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Autologous hematopoietic cell transplantation for HIV-related lymphoma: results of the BMT CTN 0803/AMC 071 trial by Joseph C. Alvarnas, Jennifer Le Rademacher,

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Presentation on theme: "Autologous hematopoietic cell transplantation for HIV-related lymphoma: results of the BMT CTN 0803/AMC 071 trial by Joseph C. Alvarnas, Jennifer Le Rademacher,"— Presentation transcript:

1 Autologous hematopoietic cell transplantation for HIV-related lymphoma: results of the BMT CTN 0803/AMC 071 trial by Joseph C. Alvarnas, Jennifer Le Rademacher, Yanli Wang, Richard F. Little, Gorgun Akpek, Ernesto Ayala, Steven Devine, Robert Baiocchi, Gerard Lozanski, Lawrence Kaplan, Ariela Noy, Uday Popat, Jack Hsu, Lawrence E. Morris, Jason Thompson, Mary M. Horowitz, Adam Mendizabal, Alexandra Levine, Amrita Krishnan, Stephen J. Forman, Willis H. Navarro, and Richard Ambinder Blood Volume 128(8): August 25, 2016 ©2016 by American Society of Hematology

2 OS and PFS. OS (A) and PFS (B) for 40 patients undergoing autologous hematopoietic cell transplantation. OS and PFS. OS (A) and PFS (B) for 40 patients undergoing autologous hematopoietic cell transplantation. OS (C) and PFS (D) for the subgroups of patients with non-Hodgkin and Hodgkin lymphoma, respectively. Prg., progression. Joseph C. Alvarnas et al. Blood 2016;128: ©2016 by American Society of Hematology

3 CD4+ T-cell reconstitution before and after AHCT
CD4+ T-cell reconstitution before and after AHCT. CD4+ T cells are expressed as an absolute number. CD4+ T-cell reconstitution before and after AHCT. CD4+ T cells are expressed as an absolute number. Joseph C. Alvarnas et al. Blood 2016;128: ©2016 by American Society of Hematology

4 Spaghetti diagram of HIV viral load for undergoing AHCT for HRL
Spaghetti diagram of HIV viral load for undergoing AHCT for HRL. The HIV viral load is expressed as a log viral load. Spaghetti diagram of HIV viral load for undergoing AHCT for HRL. The HIV viral load is expressed as a log viral load. The detection limits of the assay were 50 copies HIV/mL. Joseph C. Alvarnas et al. Blood 2016;128: ©2016 by American Society of Hematology

5 OS and PFS for HIV-infected and noninfected patients.
OS and PFS for HIV-infected and noninfected patients. Comparison of OS (A) and PFS (B) between HIV-infected patients treated under BMT CTN 0803/AMC 071 vs 151 matched controls from the CIBMTR data registry. Joseph C. Alvarnas et al. Blood 2016;128: ©2016 by American Society of Hematology


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